Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition

作     者：Satoshi Mamori Tadashi Asakura Kiyoshi Ohkawa Hisao Tajiri 

作者机构：Division of Gastroenterology and HepatologyDepartment of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan Department of Biochemistry 1The Jikei University School of MedicineTokyo 105-8461Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第40期

页      面：5306-5311页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Survivin Hepatocellular carcinoma Hypoxia 

摘      要：AIM： To investigate the expression of survivin during the early stages of hepatocellular cardnoma （HCC）. METHODS： Immunohistochemical expression of survivin in liver tumor and non-tumor tissue specimens taken from 17 patients was compared. In addition, to determine the survivin expression in response to anticancer drugs in early stage HCC, the survivin expression was determined after the treatment of the HCC cells with anti-cancer drugs under hypoxic culture conditions. RESULTS： Survivin proteins were expressed in 64.7% of cells in early HCC specimens. A correlation between the survivin expression rate in the peritumoral hepatocytes and the rate of expression in the HCC specimens （low-rate group vs high-rate group） was observed. The survivin protein concentration in HCC cells was increased by the combination of hypoxia and anti-cancer drugs. CONCLUSION： This study suggests that survivin could be used as a therapeutic target in early HCC.