Subcellular expression of maspin – from normal tissue to tumor cells
Subcellular expression of maspin – from normal tissue to tumor cells作者机构：Department of Pathology University of MedicinePharmacy Sciences and Technology of Tirgu-Mures Department of Pathology Clinical County Emergency Hospital
出 版 物：《World Journal of Meta-Analysis》 (世界荟萃分析杂志)
年 卷 期：2019年第7卷第4期
页 面：142-155页
学科分类：10[医学]
基 金：Supported by Romanian National Authority for Scientific Research CNCS–UEFISCDI No.20PCCF/2018 code:PN-Ⅲ-P4-IDPCCF-2016-0006
主 题：Maspin SerpinB5 Prognosis Cancer Tumor suppressor
摘 要：Maspin or SerpinB5, a member of the serine protease inhibitor family, was shown to function as a tumor suppressor, especially in carcinomas. It seems to inhibit invasion, tumor cells motility and angiogenesis, and promotes apoptosis. Maspin can also induce epigenetic changes such as cytosine methylation, de-acetylation,chromatin condensation, and histone modulation. In this review, a comprehensive synthesis of the literature was done to present maspin function from normal tissues to pathologic conditions. Data was sourced from MEDLINE and PubMed. Study eligibility criteria included: Published in English, between 1994 and 2019, specific to humans, and with full-text availability. Most of the 118 studies included in the present review focused on maspin immunostaining and m RNA levels. It was shown that maspin function is organ-related and depends on its subcellular localization. In malignant tumors, it might be downregulated or negative(e.g., carcinoma of prostate, stomach, and breast) or upregulated(e.g.,colorectal and pancreatic tumors). Its subcellular localization(nuclear vs cytoplasm), which can be proved using immunohistochemical methods, was shown to influence both tumor behavior and response to *** the number of maspin-related papers increased, the exact role of this protein remains unknown, and its interpretation should be done with extremely high caution.
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