Radiofrequency deep hyperthermia combined with chemotherapy in the treatment of advanced non-small cell lung cancer

作     者：Wen-Hui Yang Jun Xie Zhi-Yong Lai Mu-Dan Yang Ge-Hong Zhang Yuan Li Jian-Bing Mu Jun Xu Yang Wen-Hui;Xie Jun;Lai Zhi-Yong;Yang Mu-Dan;Zhang Ge-Hong;Li Yuan;Mu Jian-Bing;Xu Jun

作者机构：Department of Biochemistry and Molecular BiologyShanxi Medical UniversityTaiyuanShanxi 030001China Shanxi Academy of Medical SciencesShanxi Dayi HospitalTaiyuanShanxi 030032China Shanxi Province Cancer HospitalAffiliated Cancer Hospital of Shanxi Medical UniversityTaiyuanShanxi 030013China The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Thoracic SurgeryNational Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Laboratory of Malaria and Vector ResearchNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthRockvilleMD 20852USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2019年第132卷第8期

页      面：922-927页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：the Scientific Research Foundation of Shanxi Province Healthy Commission(No.2017068) Shanxi Province Science Foundation for Youths(No.201801D221259). 

主　　题：Advanced non-small cell lung cancer Chemotherapy Combination therapy Hyperthermia 

摘      要：Background:In the era of precision medicine,chemotherapy is still considered the cornerstone of treatment for lung cancer patients without gene mutations.How to reduce the toxicity and increase the efficiency of chemotherapy is worth exploring.This study aimed to investigate the curative effects and safety of hyperthermia combined with chemotherapy(HCT)for advanced patients with non-small cell lung cancer(NSCLC),especially those with malignant pleural effusion.Methods:We retrospectively evaluated medical records of 93 patients with advanced NSCLC(stage IIIB-IV)from March 2011 to January 2014.The patients were divided into HCT and chemotherapy(CT)groups.The HCT group was treated with gemcitabine and cisplatin(GP)regimen combined with regional radiofrequency deep hyperthermia,while the CT group was treated with GP regimen only.Those with malignant pleural effusion extra underwent thoracentesis and intrapleural injection chemotherapy combined with hyperthermic or not.Clinical treatment results and adverse reactions were compared and analyzed after treatment.SPSS 19.0 software(SPSS Inc.,USA)was used for statistical data processing.P values less than 0.05 were accepted to be statistically significant.Results:Among the 93 patients,HCT group included 48 patients(16 patients with malignant pleural effusion),CT group included 45 patients(10 patients with malignant pleural effusion).There was no significant difference between the two groups in patient characteristics.The overall response rate(ORR)of pleural effusions was much better in HCT group than that in CT group(81.2%vs.40.0%,P=0.046).The patients in HCT group had lower incidence rate of weakness(12.5%us.46.7%,χ^2=13.16,P0.001)and gastrointestinal(25.0%vs.77.8%,χ^2=25.88,P0.001)adverse reactions than that in CT group.The objective tumor response and survival showed no significant differences.Conclusions:Hyperthermia combined with chemotherapy might lead to the development of better therapeutic strategy for advanced NSCLC with malignant pleural effusion patients.Also,it could greatly reduce the chemotherapy toxic effects in the incidence of weakness and gastrointestinal adverse reactions in advanced NSCLC patients.