人参、白芍和紫河车混合提取物生血丹的生血作用

作     者：dju.ac.kr 

作者机构：Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Vaccine Institute Seoul National University Campus 151-742 Institute of Traditional Medicine and Bioscience Daejeon University 韩国 Daejeon 301-724 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2003年第24卷第2期

页      面：120-126页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：生血丹 人参 白芍 紫河车 血细胞生成 

摘      要：AIM: To examine the efficacy of Saenghyuldan and its components, Ginseng Radix, Paeoniae Radix Alba, and Hominis Placenta extracts (SHD, GR, PRA, and HP, respectively) on the hemopoiesis in a myelosuppression model system. METHODS: Susceptibility to cyclophosphamide (CP) and S 180 carcinoma was determined in SHD, GR,PRA, and HP-treated mice. Analysis of peripheral blood and bone marrow cells was demonstrated by changes in cell types and histopathologic examination. The expression of cytokine mRNAs involved in hemopoiesis was examined by RT-PCR. RESULTS: SHD and its seperated components (GR, HP, and PRA, respectively) significantly increased the survival in CP-and S 180-treated mice. The hematology data demonstrated that all the agents augmented monocyte and leucocyte counts in the peripheral blood and increased bone marrow density and the ratio of leukocyte to erythrocyte in the bone marrow. These findings were positively correlated with the up-regulation of cytokine mRNA expression such as granulocyte colony-stimulating factor (GM-CSF), erythropoietin (EPO), thrombopoietin (TPO), stem cell factor (SCF), and c-Kit. CONCLUSION: SHD is an effective remedy for the bone marrow failure and myelosuppression occurring during chemotherapy.