Comparing the effects of different drugs on postoperative cognitive dysfunction in elderly patients

作     者：Liu-Jia-Zi Shao Fu-Shan Xue Rui-Juan Guo Li Zheng Shao Liu-Jia-Zi;Xue Fu-Shan;Guo Rui-Juan;Zheng Li

作者机构：Department of AnesthesiologyBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2019年第132卷第8期

页      面：1007-1008页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：postoperative cognitive dysfunction(POCD) elderly patients spinal-epidural anesthesia 

摘      要：To the Editor:In a randomized controlled preliminary trial comparing effects of propofol,dexmedetomidine,and midazolam on postoperative cognitive dysfunction(POCD)in elderly patients undergoing hip or knee arthroplasty with combined spinal-epidural anesthesia,Li et al[1]showed that intraoperative sedation with propofol compared to dexmedetomidine can significantly decrease risk of *** that POCD is associated with major adverse consequences,for example,an increased mortality rate,reduced quality of life,and delayed long-term recovery,[2]their findings have potential ***,we note that this finding is totally different from the results of a recent large randomized controlled study in elderly patients undergoing hip arthroplasty with the peripheral nerve block,in which patients sedated with dexmedetomidine have a lower risk of POCD than those sedated with propofol.