An efficient synthesis of some new 3-bipyridinyl substituted coumarins as potent antimicrobial agents

作     者：Hemali B.Lad Rakesh R.Giri D.I.Brahmbhatt 

作者机构：Department of ChemistrySardar Patel University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第3期

页      面：227-229页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 0703[理学-化学] 10[医学] 

基　　金：Finaneial assistance to HJP and RRG from the UGC 

主　　题：Antimicrobial activityBipyridinyl coumarinsCoumarinsKrohnke's reaction 

摘      要：As a part of the ongoing studies in developing new antimicrobials, a series of structurally novel 3- bipyridinyl substituted coumarin derivatives 4a-f and Sa-f were synthesized by a single-step reaction protocol under Krohnke＇s reaction conditions. ]H NMR, 13C NMR, IR and mass spectral techniques were employed for the structural elucidation of the synthesized compounds. An evaluation of antimicrobial activity showed that almost all compounds exhibited better results than the referenced drugs. Among the synthesized derivatives 4f, $a and Sd were found to be the most potent analogs. Thus they could be promising lead for novel drugs.