Percutaneous Radiofrequency Ablation for Hepatic Malignancies

作     者：ZHANGZhijian WUMengchao 等 ZHANG Zhijian;WU Mengchao;CHEN Han

作者机构：EasternHepatobiliarySurgeryHospitalSecondMilitaryMedicalUniversityShanghai200438China 

出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)

年 卷 期：2002年第1卷第3期

页      面：159-162页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Shanghai Scientific and Technological development foundation  (014119043) 

主　　题：肝脏恶性肿瘤 经皮射频热凝 治疗 临床疗效 MRI 

摘      要：Objective To study the therapeutic efficay of percutaneous radiofrequency ablation(PRFA)for hepatic malignancies and to definr its indications and its criteria of the curative *** In 100 patients with histologically of clinically confirmed hepatocellular carcinoma(HCC)or liver metastases we performed PRFA under ultrasound guidance using Le Veen multipolar array meedle electrode and RF 2000 *** patients were followed to identify complications and to assess treatment *** PRFA was performed in 76 patients with HCC and in 24 with liver *** Alpha-fetoprotein(AFP)levles of the AFP positive HCC patients with inoperable small HCCs decreased to normal in 75.0%(21/28)and decreased markedly in 21.4%(6/28).Complete necrosis of small hepatic malignancies,documented by magnetic resonance imaging(MRI)was achieved in 85.9%(61/71).If the tumor shows iso-or hyper-intensity on Ti-weighted images,and relative hypointensity on T2-weighted images,and no enhanced intensity on dynamic contrast-enhanced MR imaging,it is considered completely *** PRFA is a novel local thermal palliative therapy for small hepatic malignancies that is minimally invasive,safe and *** patients with large lesions it can be combined with transarterial chemoembolization(TACE).Critera for curative treatment are normalization of serum AFP and /or MRI or CT scan findings showing complete necrosis.