High-dose Iodized Oil Transcatheter Arterial Chemoembolization For Patients with Large Hepatocellular Carcinoma
High-dose Iodized Oil Transcatheter Arterial Chemoembolization For Patients with Large Hepatocellular Carcinoma作者机构：Department of Hepatobiliary Cancer Center of Sun Yet-sen University of Medical Sciences 651 Dongfeng Road East Guangzhou 510060 China. minshan@***
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2002年第8卷第1期
页 面：74-78页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the"9.5"National Major Project of National Committee of Sciences and Technology No.96-907-03-02
摘 要：AIM:To conduct a randomized trial to evaluate the role ofusing high-dose iodized oil transcatheter arterialchemosmbolization(TACE)in the treatment of largehepatocellular carcinoma(HCC).METHODS:From January 1993 to June 1998,473 patientswith unresectable hepatocellular carcinoma ware divided intotwo groups:216 patients in group A received more than20mL iodized oil during the first TACE treatment;257patients in group B received 5-15mL iodized oil in the *** Child s classification and ICG-R15 for evaluatingthe liver function of the patients ware done before *** the TACE procedure the catheters wasinserted into the target artery selectively and the tumorvessels ware demonstrated with contrast medium in thehepatic *** anticancar drugs mixed withiodized oil(Lipiodol)ware Epirubicin and *** A,112 cases received 20-29mL Lipiodol in the firstprocedure,85 cases 30-39mL,19 cases more than *** largest dose was 53 mL and the average dose *** group B,119 cases received 5-10mL Lipiodol,138 cases received 11-15mL,and the average dose ***:High-dose Lipiodol chemoembolization causedtolerable side effects and a little hurt to the liver function inthe patients with Child grade A or ICG-R1520 had higher risk ofliver failure after high-dose *** type Ⅱ and type Ⅱlipiodol accumulations in CT scan after 4 weeks of TACEware seen in the group A patients than those in the group Bpatients(P0.01).The resection rate and complete tumornecrosis rate in group A ware higher than those of group B(P0.05).The 1-,2-,3-year survival rates of group Apatients with Child grade A ware 79.2%,51.8% and 34.9%,respectively,better then those of group B(P0.001).CONCLUSION:High-dose Lipiodol can result in morecomplete tumor necrosis by blocking both arteries and small portal veins of the ***-dose TACE for treatment oflarge and hypervascular hepatocallular carcinoma ispractic
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