Synthesis and Immunosuppressive Activity of New Amino Alcohol Derivatives(Ⅰ)

作     者：MI Hao-yu CUI Lin-lin ZHANG Qun-li LI Fang JIANG Tao LIANG Yong-tao WANG En-si 

作者机构：College of Life Science Jilin University Changchun 130012 R R. China School of Pharmacy Jilin University Changchun 130021 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2011年第27卷第4期

页      面：614-618页

核心收录：

学科分类：0710[理学-生物学] 090403[农学-农药学(可授农学、理学学位）] 07[理学] 071009[理学-细胞生物学] 09[农学] 0904[农学-植物保护] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co.Ltd 

主　　题：Immunosuppressant Amino alcohol derivative Bucherer-Bergs reaction 

摘      要：A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood *** structures were confirmed by means of 1H NMR,13C NMR,IR and *** of the compounds display moderate to potent inhibitory *** 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.