Hepatic encephalopathy therapy:An overview

作     者：Oliviero Riggio Lorenzo Ridola Chiara Pasquale 

作者机构：Department of Clinical MedicineCentre for the Diagnosis and Treatment of Portal Hypertension"Sapienza" University of Rome 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2010年第1卷第2期

页      面：54-63页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Complications of cirrhosis Porto-systemicshunts Ammonia Nitrogen metabolism Transjugular intrahepatic portosystemic shunt 

摘      要：Type-C hepatic encephalopathy(HE) is a severe complication of cirrhosis,which seriously affects quality of life and is strongly related to patient *** based on a classical pharmacological approach that is aimed at reducing the production of gut-derived toxins,such as ammonia,is still under ***,results obtained from clinical trials do not support any specific treatment for HE and our competence in testing old and new treatment modalities by randomized controlled trials with appropriate clinically relevant end-points urgently needs to be *** the other hand,patients who are at risk for HE are now identifiable,based on studies on the natural history of the ***,very few studies that are specifically aimed at establishing whether HE may be prevented are available or in *** studies have looked at non absorbable disaccharides or antibiotics and other treatment modalities,such as the modulation of intestinal *** the treatment of severe stage HE,artificial liver supports have been tested with initial positive results but more studies are needed.