Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

作     者：Sarah H. Alfaraj Jaffar A. Al-Tawfiq Talal A. Altuwaijri Ziad A. Memish 

作者机构：University of British ColumbiaVancouverV6T 1Z4Canada Corona CenterInfectious Diseases DivisionDepartment of PediatricPrince Mohamed Bin Abdulaziz HospitalMinistry of HealthRiyadh 11676Saudi Arabia Indiana University School of MedicineIndianapolisIN 46202USA Johns Hopkins Aramco HealthcareDhahran 31311Saudi Arabia Department of SurgeryKing Saud UniversityRiyadh 11692Saudi Arabia College of MedicineAlfaisal UniversityRiyadh 11533Saudi Arabia Infectious Diseases DivisionDepartment of MedicinePrince Mohamed Bin Abdulaziz HospitalMinistry of HealthRiyadh 11676Saudi Arabia Department of Global HealthRollins School of Public HealthEmoiy UniversityAtlantaGA 30322USA 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2019年第13卷第1期

页      面：126-130页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Middle East respiratory syndrome coronavirus MERS-CoV pregnancy pediatrics 

摘      要：Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%—60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases. In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS. Five patients had no underlying medical illnesses, and three patients were asymptomatic. Of the seven cases, four (57%) patients sought medical advice within 1-7 days from the onset of symptoms. The three other patients (43%) were asymptomatic and were in contact with patients with confirmed diagnosis of MERS-CoV. The most common presenting symptoms were fever (57%), cough (14%), shortness of breath (14%), vomiting (28%), and diarrhea (28%). Two (28.6%) patients had platelet counts of 150 ×10^9/L, and one patient had an underlying end-stage renal disease. The remaining patients presented with normal blood count, liver function, and urea and creatinine levels. The documented MERS-CoV Ct values were 32 38 for four of the seven cases. Two patients (28.6%) had abnormal chest radiographic findings of bilateral infiltration. One patient (14.3%) required ventilator support, and two patients (28.6%) required oxygen supplementation. All the seven patients were discharged without complications.