^(18)F-PBR06 PET/CT imaging of inflammation and differentiation of lung cancer in mice

作     者：He Zhang Hui Tan Wu-Jian Mao Jun Zhou Zhe-Quan Fu Yan Hu Jie Xiao Qing-Yu Lin Hong-Cheng Shi Deng-Feng Cheng 

作者机构：Shanghai Institute of Medical Imaging Department of Nuclear MedicineZhongshan HospitalFudan University Institute of Nuclear MedicineFudan University 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2019年第30卷第5期

页      面：122-129页

核心收录：

学科分类：08[工学] 0827[工学-核科学与技术] 

基　　金：funded in part by the National Natural Science Foundation of China(Nos.11875114,81471706,and 81871407) Science and Technology Commission of Shanghai Municipality(No.16410722700) sponsored by the Shanghai Sailing Program(No.17YF1417400) 

主　　题：TSPO Macrophage PET/CT Inflammation Lung cancer 

摘      要：The present study explored the 18-kDa translocator protein radioligand ^(18)F-PBR06 as a PET imaging biomarker for diagnosis of inflammation and compared it with ^(18)F-FDG for differentiation of inflammation and lung tumors in animals.^(18)F-PBR06 was synthesized with an average decay-corrected radiochemical yield of 30–40%(end of synthesis, EOS), and the radiochemical purity was greater than 99%. The inflammation-to-blood ratio of ^(18)FPBR06(3.53 ± 0.26) was higher than the tumor-to-blood ratio(1.77 ± 0.35)(P \ 0.001). The inflammation-tomuscle ratio of ^(18)F-PBR06(2.33 ± 0.64) was also higher than the tumor-to-muscle ratio(1.45 ± 0.14)(P = 0.036).Micro-PET/CT images showed high uptake of ^(18)F-FDG in both inflamed muscles and lung tumor tissues. However,^(18)F-PBR06 uptake in inflamed muscles remained higher than that in the lung tumor tissues, following 90 min of dynamic Micro-PET/CT imaging. Further, macrophages in the inflammatory regions showed a higher fluorescence signal than in lung tumor tissues. Results of the study confirmed that ^(18)F-PBR06 PET/CT imaging allowed for diagnosis of inflammation. Moreover,^(18)F-PBR06 uptake in the inflammatory regions was significantly higher than in lung tumor tissues, suggesting that ^(18)F-PBR06 PET/CT imaging has potential to differentiate between peripheral lung cancer and inflammation nodules.