Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

作     者：Prakash Khadka Jieun Ro Hyeongmin Kim Iksoo Kim Jeong Tae Kim Hyunil Kim Jae Min Cho Gyiae Yun Jaehwi Lee 

作者机构：College of PharmacyChung-Ang UniversitySeoul 156-756Republic of Korea Department of Food Science and TechnologyChung-Ang UniversityAnseong 456-756Republic of Korea 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2014年第9卷第6期

页      面：304-316页

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education Science and Technology(2012-0001499) 

主　　题：Particle technology Drug solubility Poorly water soluble drug Solubility enhancement Dissolution 

摘      要：Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral *** particle technology involves several approaches from the conventional size reduction processes to the newer,novel particle technologies that modify the solubility properties of the drugs and produce solid,powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage *** review highlights the solid particle technologies available for improving solubility,dissolution and bioavailability of drugs with poor aqueous solubility.