Clinical characteristics and current management of hepatitis B and C in China

作     者：Yong-Tao Sun Yue-Xin Zhang Hong Tang Qing Mao Xiao-Zhong Wang Ling-Yi Zhang Hong Chen Ying-Na Zhong Shu-Mei Lin Da-Zhi Zhang 

作者机构：Department of Infectious DiseasesTangdu HospitalAffiliated to the Fourth Military Medical University the First Affiliated Hospital of Xinjiang Medical University West China HospitalSichuan University the First Affiliated Hospital of the Third Military Medical University Traditional Chinese Medicine Hospital of Xinjiang Uygur Administrative Region the Second Affiliated Hospital of Lanzhou University the First Affiliated Hospital of Lanzhou University People’s Hospital of Xinjiang Uygur Administrative Region the First Affiliated Hospital of Xi'an Jiaotong University the Second Affiliated Hospital of Chongqing Medica University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第37期

页      面：13582-13590页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Financial support for this study was provided by Merck Sharp and Dohme(China)Ltd 

主　　题：Hepatitis B Hepatitis C Clinical characteristics Treatment 

摘      要：AIM: To describe a population of outpatients in China infected by hepatitis B virus (HBV) and/or hepatitis C virus (HCV), and assess their current management status. METHODS: A multicenter, cross-sectional study of HBV- and/or HCV-infected patients was conducted from August to November, 2011 in western China. Patients = 18 years of age with HBV and/or HCV infections who visited outpatient departments at 10 hospitals were evaluated, whether treated or not. Data were collected on the day of visit from medical records and patient interviews. RESULTS: A total 4010 outpatients were analyzed, including 2562 HBV- infected and 1406 HCV-infected and 42 HBV/HCV co-infected patients. The median duration of documented infection was 7.5 years in HBV- infected and 1.8 years in HCV-infected patients. Cirrhosis was the most frequent hepatic complication (12.2%), appearing in one-third of patients within 3 years prior to or at diagnosis. The HCV genotype was determined in only 10% of HCV-infected patients. Biopsy data were only available for 54 patients (1.3%). Antiviral medications had been received by 58.2% of patients with HBV infection and 66.6% with HCV infection. Nucleos(t) ide analogs were the major antiviral medications prescribed for HBV- infected patients (most commonly adefovir dipivoxil and lamivudine). Ribavirin + pegylated interferon was prescribed for two-thirds of HCV-infected patients. In the previous 12 mo, around one-fifth patients had been hospitalized due to HBV or HCV infection. CONCLUSION: This observational, real-life study has identified some gaps between clinical practice and guideline recommendations in China. To achieve better health outcomes, several improvements, such as disease monitoring and optimizing antiviral regimens, should be made to improve disease management. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.