Boosting the immune response： the use of iNKT cell ligands as vaccine adjuvants

作     者：Priyanka B. SUBRAHMANYAM Tonya J. WEBB 

作者机构：Department of Microbiology and Immunology University of Maryland School of Medicine and the Marlene and Stewart Greenebaum CancerCenter Baltimore Maryland 21201 USA 

出 版 物：《Frontiers of physics》 (物理学前沿（英文版）)

年 卷 期：2012年第7卷第5期

页      面：436-444页

核心收录：

学科分类：083002[工学-环境工程] 090602[农学-预防兽医学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 09[农学] 0906[农学-兽医学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

主　　题：vaccines NKT cells and CDld 

摘      要：Natural killer T （NKT） cells comprise a small, but important T cell subset and are thought to bridge the innate and adaptive immune responses. The discovery of NKT cells and extensive research on their activating ligands have paved the way for modulation of these potent immunoregulatory cells in order to improve the outcome of various clinical conditions. Efforts to modulate NKT cell effector functions have ranged from therapy for influenza to anti- tumor immunotherapy. These approaches have also led to the use of NKT cell agonists such as a-Galactosylceramide （a- GalCer） and its analogs as vaccine adjuvants, an approach that is aimed at boosting specific B and T cell responses to a vaccine candidate by concomitant activation of NKT cells. In this review we will provide a comprehensive overview of the efforts made in using a-GalCer and its analogs as vaccine adjuvants. The diverse array of vaccination strategies used, as well as the role of NKT cell activating adjuvants will be discussed, with focus on vaccines against malaria, HIV, influenza and tumor vaccines. Collectively, these studies demonstrate the efficacy of NKT cell-specific agonists as adjuvants and suggest that these compounds warrant serious consideration during the development of vaccination strategies.