BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages

作     者：Shu-Wen Qian Meng-Yuan Wu Yi-Na Wang Ya-Xin Zhao Ying Zou Jia-Bao Pan Yan Tang Yang Liu Liang Guo Qi-Qun Tang 

作者机构：Key Laboratory of Metabolism and Molecular MedicineThe Ministry of EducationDepartment of Biochemistry and Molecular BiologyFudan University Shanghai Medical CollegeShanghai 200032China 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2019年第11卷第1期

页      面：14-25页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 

基　　金：grants from the National Natural Science Foundation of China(NSFC 81390353 to Q.-Q.T.,31571471 to Q.-Q.T.,and 31670787 to S.-W.Q.) the Ministry of Science and Technology of China(MOST 2013CB530601 to Q.-Q.T.). 

主　　题：BMP4 fat browning adipose tissue macrophages 

摘      要：Thermogenic beige fat improves metabolism and prevents obesity.Emerging evidence shows that the activation of M2 macrophages stimulates beige adipogenesis,whereas the activation of Ml macrophages,which play a major role in inflammation,impedes beige adipogenesis.Thus,the identification of factors that regulate adipose tissue macrophages(ATMs)will help clarify the mechanism involved in beiging.Here,we found that one of the secreted proteins in adipose tissue,namely,BMP4,alters the ATM profile in subcutaneous adipose tissue by activating M2 and inhibiting Ml macrophages.Mechanistically,the BMP4-stimutated p38/MAPK/STAT6/PI3K-AKT signalling pathway is involved.Meanwhile,BMP4 improved the potency of M2 macrophages to induce beige fat biogenesis.Considering that the overexpression of BMP4 in adipose tissue promotes the beiging of subcutaneous adipose tissue and improves insulin sensitivity,these findings provide evidence that BMP4 acts as an activator of beige fat by targeting immuno-metabolic pathways.