Nodular regenerative hyperplasia:Evolving concepts on underdiagnosed cause of portal hypertension

作     者：Marek Hartleb Krzysztof Gutkowski Piotr Milkiewicz 

作者机构：Department of Gastroenterology and HepatologyMedical University of Silesia40-752 KatowicePoland Liver UnitPomeranian Medical University70-111 SzczecinPoland 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第11期

页      面：1400-1409页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Nodular regenerative hyperplasia Portal hypertension Comorbidities 

摘      要：Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative *** may lead to the development of non-cirrhotic portal *** are no published systematic population studies on NRH and our current knowledge is limited to case reports and case *** may develop via autoimmune,hematological,infectious,neoplastic,or drug-related *** disease is usually asymptomatic,slowly or nonprogressive unless complications of portal hypertension *** diagnosis is made by histopathology,which demonstrates diffuse micronodular transformation without fibrous *** of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic *** the initial treatment is to address the underlying disease,ultimately the therapy is directed to the management of portal *** prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal *** this review we detail the epidemiology,pathogenesis,diagnosis,management,and prognosis of NRH.