The role of tumor size,ultrasonographic findings,and serum tumor markers in predicting the likelihood of malignant testicular histology

作     者：Gang Song Geng-Yan Xiong Yu Fan Cong Huang Yong-Ming Kang Guang-Jie Ji Jin-Chao Chen Zhong-Cheng Xin Li-Qun Zhou 

作者机构：Department of UrologyPeking University First HospitalBeijing 100034China Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing 100034China Department of UrologySuining Central HospitalSuining 629000China Department of AndrologyPeking University First HospitalBeijing 1CX3034China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2019年第21卷第2期

页      面：196-200页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：malignant likelihood predictive model testicular tumor urological oncology 

摘      要：The clin ical predictive factors for maligna nt testicular histology remain unclear because of the low prevale nee.Therefore,the aim of this study was to investigate predictors of malignant histology for testicular masses and decide more testis-sparing surgeries before surgery.This retrospective study enrolled 325 consecutive testicular mass patients who underwent radical orchiectomy(310/325)or testicular preserving surgery(15/325)from January 2001 to June 2016.The clinicopathological factors,including tumor diameter,cryptorchidism history,ultraso und fin dings,serum alpha-fetoprotein,and human chorio nic gonadotropin(HCG)levels,were collected retrospectively for statistical an alysis.A predictive no mogram was also gen erated to evaluate the qua ntitative probability.Among all patients,247(76.0%)were diagnosed with a malignant testicular tumor and 78(24.0%)with benign histology.Larger tumor diameter(percm increased,hazard ratio[HR]=1.284,P=0.036),lower ultrasound echo(HR=3.191,P=0.001),higher ultrasound blood flow(HR=3.320,P0.001),and abnormal blood HCG(HR=10.550,P0.001)were significant predictive factors for malignant disease in all testicular mass patients?The nomogram generated was well calibrated for all predicti ons of malig nant probability,and the accuracy of the model no mogram measured by HarrelTs C statistic(C-in dex)was 0.92.According to our data,the proportion of patients who underwent radical orchiectomy for benign tumors(24.0%)was much larger tha n gen erally believed(10.0%).Our results in dicated that the diameter,ultras onic echo,ultras onic blood flow,and serum HCG levels could predict the malignancy in testicular mass patients.