Drosophila as a model for antiviral immunity

作     者：Susanna Valanne Mika Rmet 

作者机构：Institute of Medical TechnologyUniversity of Tampere Department of PaediatricsTampere University Hospital 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2010年第1卷第5期

页      面：151-159页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：Supported by Grants from the Academy of Finland,the Foundation for Pediatric Research Sigrid Juselius Foundation Tampere Tuberculosis Foundation and Emil Aaltonen Foundation(to Rmet M) Competitive Research Funding of the Pirkanmaa Hospital District(to Rmet M and Valanne S) 

主　　题：Antiviral Drosophila Genetics Immune signaling Infection JAK/STAT RNA interference Virus 

摘      要：The fruit fly Drosophila melanogaster has been successfully used to study numerous biological processes including immune *** are naturally infected with more than twenty RNA viruses making it a valid model organism to study host-pathogen interactions during viral *** Drosophila antiviral immunity includes RNA interference,activation of the JAK/STAT and other signaling cascades and other mechanisms such as autophagy and interactions with other *** we review Drosophila as an immunological research model as well as recent advances in the field ofDrosophila antiviral immunity.