A Meta-analysis of the Value of vWF in the Diagnosis of Liver Cirrhosis with Portal Hypertension
作者机构：Department of Infectious DiseaseGeneral Hospital of Ningxia Medical UniversityYinchuanNingxiaChina Department of GastroenterologyMunicipal Hospital Affiliated to XuchangXuchangHenanChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2019年第7卷第1期
页 面：3-8页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This study was supported by the National Natural Science Foundation of China(No.81760363) the National Key R&D Program of China(No.2016YFD0400605) the Natural Science Foundation of Ningxia(NZ16156,2018AAC02014)
主 题：Liver cirrhosis Portal hypertension HVPG vWF
摘 要：Background and Aims:Studies have indicated that serum von Willebrand factor(vWF)has a positive correlation with hepatic venous pressure ***,information on the value of vWF in the diagnosis of liver cirrhosis with portal hypertension has been *** purpose of this meta-analysis was to assess the value of vWF in the diagnosis of liver cirrhosis with portal ***:Studies that analyzed the sensitivity,specificity,diagnostic odds ratio combined with likelihood ratios and test for heterogeneity of vWF in the diagnosis of liver cirrhosis with portal hypertension were found in the Cochrane Library,Ovid,VOS-SCI,CNKI,PubMed,Medline,EMBASE,CMB and Wanfang *** the end,the data was used to draw the summary receiver operating characteristic curve and to calculate the area under the ***:Four studies involving 662 patients were *** results showed that serum vWF in liver cirrhosis with portal hypertension were significantly higher than in those without portal *** combined was 0.823(95%CI:0.788,0.855).Specificity combined was 0.782(95%CI:0.708,0.845).+LR combined was 3.777(95%CI:2.794,5.107).-LR combined was 0.221(95%CI:0.180,0.272).Diagnostic odds ratio combined was 18.347(95%CI:11.725,28.708).The area under the curve was ***:Serum vWF can be used as an effective and feasible method for noninvasive diagnosis of liver cirrhosis with portal ***,further studies are still needed to evaluate the severity of liver cirrhosis with portal hypertension.
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