Application of Enzymatic Promiscuity in Pharmaceutical Synthesis:Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives
作者机构：Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of TechnologyHangzhou 310014P.R.China Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education College of Pharmaceutical SciencesZhejiang University of Technology Hangzhou 310014P.R.China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2019年第35卷第1期
页 面：21-25页
核心收录：
基 金：the National Natural Science Foundation of China(No.21706236) the China Postdoctoral Science Foundation (No.2016M592012) the Foundation for Selected Postdoctoral Project of Zhejiang Province,China(No.BSH1502150)
主 题：Papain Catalytic promiscuity Multicomponent reaction 1,4-Dihydropyridine calcium channel antagonist
摘 要：A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP)calcium channel antagonists felodipme, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate and ethyl 3-aminocrotonate was *** simplicity,mild reaction conditions and eco-friendliness are the key features of this protocol.
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