Electric Field Stress Simulation of Plasma Membrane Under Steep Pulsed Electric Field
Electric Field Stress Simulation of Plasma Membrane Under Steep Pulsed Electric Field作者机构：State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Chongqing 400044 China
出 版 物：《高电压技术》 (High Voltage Engineering)
年 卷 期：2009年第35卷第5期
页 面：1088-1092页
核心收录：
学科分类：071011[理学-生物物理学] 0710[理学-生物学] 0808[工学-电气工程] 080803[工学-高电压与绝缘技术] 07[理学] 08[工学]
基 金：国家自然科学基金
摘 要：The basic characteristic of electric field is that the substance in the field is in operation by the *** external electric fields,there is strong distribution of electric fields on the inside and outside surfaces of cell *** virtue of the difference of the permittivity among membrane,cytoplasm and extracellular medium,there must he electric field stress on the surface of the *** goal of the study is to research the irreversible electrical breakdown (IRE) mechanism of the malignant tumor cells under steep pulsed electric field (SPEF)from the views of *** field stress of plasma membrane under steep pulsed electric field is calculated and simulated both on malignant tumor cells and on the normal *** calculation results show that,in addition to a compressive stress normal to the membrane plane,transverse traction stresses are generated in the lateral plane of the *** lateral stress will reduce the membrane tension significantly,leading to electroporation and *** the same electric field strength,the transverse traction stress on malignant cell membrane is greatly larger than the one on normal cell ***,compared with the normal cells,the malignant tumor cells are more sensitive under the steep pulsed electric ***,steep pulsed electric field can selectively destroy the malignant tumor cells,which proved the safety of treating malignant tumors by steep pulsed electric field.
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