-94 G/A polymorphism in the dopamine D1 receptor gene is associated with schizophrenia in a Chinese Han population from Shandong province

作     者：Zhaoyun Du Guangxin Wang Yuebing Zhang Yiren Cheng Chuan'an Zhu 

作者机构：Department of Laboratory Medicine Jining Medical College Jining 272067 Shandong Province China Institute of Pediatrics Qilu Children's Hospital Shandong University Jinan 250022 Shandong Province China Department of Psychiatry Second Affiliated Hospital of Jining Medical College Jining 272051 Shandong Province China Department of Laboratory First People's Hospital of Jining Jining 272001 Shandong Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第19期

页      面：1484-1487页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：the Scientific Foundation of Shandong Population and Family Planning  No. 2006-7 

主　　题：dopamine D1 receptor gone single nucleotide polymorphism schizophrenia 

摘      要：The correlation between -94 G/A polymorphism in the dopamine D1 receptor gone and schizophrenia remains poorly understood despite extensive research. This study sought to evaluate the genotypes and allele frequencies of the -94 G/A polymorphism in the dopamine D1 receptor gone by real-time PCR using TaqMan fluorescent probes. One hundred and sixty-two patients with schizophrenia and 101 healthy controls living in Shandong province of China were evaluated. Experimental results showed that the G/A genotype distribution was significantly higher in the schizophrenia patients than in healthy controls. The frequencies of G allele and A allele were not significantly different between the schizophrenia patients and the controls. Thus, the -94 G/A polymorphism in the dopamine D1 receptor gone was found to be associated with schizophrenia in a Chinese Han population from Shandong province.