Review:Global nutrient profiling by Phenotype MicroArrays:a tool complementing genomic and proteomic studies in conidial fungi

作     者：Lea ATANASOVA Irina S.DRUZHININA 

作者机构：Research Area of Gene Technology and Applied BiochemistryInstitute of Chemical EngineeringVienna University of Technology A-1060 ViennaAustria 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2010年第11卷第3期

页      面：151-168页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学] 

基　　金：Project (No.FWF P-P17859-B06) supported by the Austrian Science Foundation 

主　　题：Biolog Phenotype MicroArray Mitosporic fungi Carbon metabolism Trichoderma Aspergillus Biotechnology 

摘      要：Conidial fungi or molds and mildews are widely used in modern biotechnology as producers of antibiotics and other secondary metabolites,industrially important enzymes,chemicals and *** are also important pathogens of animals including humans and agricultural *** various applications and extremely versatile natural phenotypes have led to the constantly growing list of complete genomes which are now *** genomics and proteomics widely exploit the genomic information to study the cell-wide impact of altered genes on the phenotype of an organism and its *** allows for global analysis of the information flow from DNA to RNA to protein,but it is usually not sufficient for the description of the global phenotype of an *** recently,Phenotype MicroArray (PM) technology has been introduced as a tool to characterize the metabolism of a (wild) fungal strain or a *** this article,we review the background of PM applications for fungi and the methodic requirements to obtain reliable *** also report examples of the versatility of this tool.