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Imbalance of Interleukin 18 and Interleukin 18 Binding Protein in Patients with Lupus Nephritis

Imbalance of Interleukin 18 and Interleukin 18 Binding Protein in Patients with Lupus Nephritis

作     者:Dong Liang Wenfeng Ma Cuiwei Yao Huafeng Liu Xiaowen Chen 

作者机构:Insfitute of Nephrology Guangdong Medical College Zhanjiang Guangdong 524001 China 

出 版 物:《Cellular & Molecular Immunology》 (中国免疫学杂志(英文版))

年 卷 期:2006年第3卷第4期

页      面:303-306页

核心收录:

学科分类:0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基  金:supported by a grant from Guangdong Natural Science Foundation(5011589) a PhD scholarship of Guangdong Medical College(200301) 

主  题:IL-18 IL-18 binding protein lupus nephritis primary nephrotic syndrome 

摘      要:To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by ELISA and RT-PCR respectively. The ratio of IL-18/IL-18BP was also calculated. Both plasma IL-18 and IL-18BP increased significantly in LN patients while only IL-18BP increased in PNS, which resulted in an elevated ratio of IL-18/IL-18BP in LN but not in PNS patients when compared with normal controls. In contrast, increased level of IL-18 mRNA was only detected in LN but not in PNS group, although IL-18BP mRNA expressions in PBMCs in both groups were higher than that in control. The imbalance of IL-18 and IL-18BP might be involved in the pathogenesis of LN, based on which a therapeutic approach is valuable to be developed for LN.

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