Expression of Retroviral Mediated Wild Type p53 Gene in Laryngocarcinoma and Fibrosarcoma Cell Lines and Its Inhibitory Effects on Cancer Growth

作     者：陈晓巍 

作者机构：Dept.of OtolaryngologyPeking Union Medical College HospitalBeijing 100730P.R.China 

出 版 物：《High Technology Letters》 (高技术通讯（英文版）)

年 卷 期：1996年第2卷第1期

页      面：103-106页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the High Technology Research and Development Programme of China 

主　　题：P53 gene Laryngocarcinoma Fibrosacoma 

摘      要：The accumulated evidence indicates that head and neck cancers arise due to multiple genetic changes in both dominant oncogenes and tumor suppressor genes. In this report we examined whether the wild-type p53 gene was able to suppress in vitro and in vivo cellular growth of laryngocarcinoma cell line and fibrosarcoma which carried multiple genetic abnormalities. Introduction of retroviral mediated wild-type p53 complementary DNA into laryngocarcinoma cell line (Hep2) and fibrosarcoma cell line (MDAH 041) carrying either a homozygous deletion or a missense in the p53 gene greatly suppressed tumor cell growth and the malignant phenotype of the cancer cells was reversed.