Immunogenetic characteristics of patients with autoimmune gastritis

作     者：Aino Mirjam Oksanen Katri Eerika Haimila Hilpi Iris Kaarina Rautelin Jukka Antero Partanen 

作者机构：Herttoniemi HospitalHealth Centre Finnish Red Cross Blood ServiceClinical Laboratory Department of Bacteriology and Immunology Haartman InstituteUniversity of Helsinki HUSLABHelsinki University Central Hospital Department of Medical SciencesUniversity and University Hospital of Uppsala Finnish Red Cross Blood ServiceResearch and Development 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第3期

页      面：354-358页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by A grant from the Research Unit of the Health Centre City of Helsinki 

主　　题：Atrophic gastritis Autoimmune diseases Cytokines Genetic polymorphisms Human leukocyte antigens Killer cell immunoglobulin-like receptor 

摘      要：AIM:To explore whether predisposition to autoimmune gastritis (AIG) is found in human leukocyte antigen (HLA), cytokine or killer cell immunoglobulin-like receptor (KIR) gene ***: Twelve Finnish patients with autoimmunetype severe atrophy of the gastric corpus were included. The patients serum was analyzed for pepsinogen-interleukin (IL)-1 gene cluster, IL-2, IL-4, IL-6, IL-10, IL-12, interferon γ, transforming growth factor β, and tumor necrosis factor α. Variation in KIR genes was also explored. The results were compared with prevalence of the polymorphisms in Finnish or European ***: All patients had pepsinogen-CONCLUSION: As explored with modern DNA-based methods, HLA-DRB1*04 and DQB1*03 alleles, but not HLA-B8-DRB1*03, may predispose to AIG.