Pros and Cons: Autophagy in Acute Spinal Cord Injury

作     者：Zheng Li Tianshi Chen Yuanwu Cao Xiaoxing Jiang Haodong Lin Jian Zhang Zixian Chen 

作者机构：Department of Orthopedics Zhongshan Hospital Fudan University Shanghai 200032 China Department of Orthopedics People’s Hospital of Boluo County Huizhou 516100 China Department of Orthopedic Surgery Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai 200080 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2019年第35卷第5期

页      面：941-945页

核心收录：

学科分类：10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81301047) 

主　　题：Pros Cons: Autophagy Acute Spinal Cord Injury 

摘      要：Autophagy plays an important role in the development and pathogenesis of various diseases. It can be induced by a variety of events such as hypoxia, nutrient-starvation, and mechanical damage. Many neurological disorders such Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, cerebral ischemia, and acute spinal cord injury (ASCI), are closely related to autophagy. However, therapeutic strategies to manipulate autophagy have not yet been fully deciphered due to the limited knowledge of the molecular mechanisms underlying autophagy in these disorders.