Emodin inhibits dietary induced atherosclerosis by antioxidation and regulation of the sphingomyelin pathway in rabbits

作     者：HEI Zi-qing HUANG He-qing TAN Hong-mei LIU Pei-qing ZHAO Ling-zhi CHEN Shao-rui HUANG Wen-ge CHEN Feng-ying GUO Fen-fen 

作者机构：Department of Anesthesiology Third Affiliated Hospital SunYat-sen University Guangzhou 510630 China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510080 China Zhongshan Medical College Sun Yat-sen University Guangzhou510080 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2006年第119卷第10期

页      面：868-870页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by Guangdong Provincial Natural Science Grant (No. 001399 04105337) 

主　　题：SIGNAL-TRANSDUCTION CERAMIDE 

摘      要：Emodin is an important component of rhubarb, a traditional Chinese herb. Previous studies in vitro showed that emodin inhibited the proliferation of human vascular smooth muscle cells, indicating the possible inhibitive effect of emodin on atherosclerosis. The present research evaluated the effect of emodin on the formation of atherosclerotic lesion induced by high cholesterol and fat diet in rabbits and the mechanism of this effect.