Spatial Genetic Structure of Two HIV-I-resistant Polymorphisms (CCR2-64 Ⅰ and SDF1-3’A) Alleles in Population of Shandong Province, China

作     者：FU-ZHONG XUE JIE-ZHEN WANG DAO-XIN MA GUO-RONG LI PING HU FU-ZHONG XUE?,2, JIE-ZHEN WANG?, DAO-XIN MA#, GUO-RONG LI+, AND PING HU? ?Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;#Qilu Hospital, Shandong University, Jinan 250012, Shandong, China;+Center for Disease Control and Prevention of Shandong Province, Jinan 250012, Shandong, China

作者机构：Department of Epidemiology and Biostatistics School of Public Health Shandong University Jinan 250012 ShandongChina Qilu Hospital Shandong University Jinan 250012 Shandong China Center for Disease Control and Prevention of Shandong Province Jinan 250012 Shandong China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2005年第18卷第4期

页      面：241-253页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina(grantNo.30170527)andtheScienceFoundationofHealthBureauofShandongProvince China 

主　　题：Spatial genetic structure Chemokine receptors HIV-Ⅰ Resistant polymorphism Relative hazard 

摘      要：To explore the spatial genetic structure of two HIV-Ⅰ-resistant polymorphisms （CCR2-64 Ⅰ and SDF1-3＇A） alleles in the population of Shandong Province, China. Methods Using the techniques of spatial stratified sampling and spatial statistics, the spatial genetic structure of the locus （CCR2-64 Ⅰ and SDF1-3＇A）, which was shown to be important co-receptor for HIV infection, was quantified from the populations of 36 sampled counties of Shandong Province, and a total of 3147 and 3172 samples were taken for testing CCR2-64Ⅰ and SDF1-3＇A respectively from individuals without known history of HIV-Ⅰ infection and AIDS symptoms. Results There were significantly spatial genetic structures of the two alleles at different spatial distance classes on the scale of populations, but on the scale of individuals, no spatial structure was found in either the whole area of Shandong Province or the area of each sampled county. Although the change of frequencies of the two alleles with geographic locations in Shandong Province both showed gradual increase trends, their changing directions were inverse. The frequency of CCR2-64Ⅰallele gradually increased from the southwest to the northeast, while the frequency of SDF1-3＇A allele gradually increased from the northeast to the southwest. However the RH to AIDS of combined types of their different genotypes did not represent obvious geographic diversity on the whole area of the Province. Conclusion The frequency of allele usually has some spatial genetic structures or spatial autocorrelation with different spatial distance classes, but the genotypes of individuals have random distribution in the same geographic area. Evaluating spatial distribution of the genetic susceptibility of HIV （AIDS） to CCR2-64Ⅰand SDF1-3＇A alleles, should focus on the frequencies of combined genotypes of CCR2 and SDFI based on the two-locus genotypes of each individual rather than the frequencies of CCR2-641 and SDF1-3＇A alleles.