与临床诊断相关的组织病理学研究丹麦1978—2002年的肉瘤样病变

作     者：Φstergaard J. Prause J.U. Heegaard S. 潘佳鸿 

作者机构：Eye Pathology InstituteUniversity of CopenhagenFrederikV's Vej 11 DK- 2100 Copenhagen Denmark 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2006年第2卷第8期

页      面：9-9页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：瘤样病变 临床诊断 病理学研究 瘤前病变 癌前病变 切除物 绒毛状瘤 病理学检查 基底细胞癌 临床病 

摘      要：Purpose: To carry out a retrospective clinicopathological evaluation of caruncular lesions. Methods: Data were collected from all surgically removed and histopathologically evaluated caruncular lesions registered by Danish pathology departments during the 25- year period 1978- 2002. Results: A total of 574 caruncular lesions were identified. The number of caruncular lesions increased significantly during the 25- year period. This was due to an increase in the number of benign lesions, whereas the number of premalignant and malignant lesions remained constant. A total of 550 (96% ) of the lesions were benign. Naevus (n=248, 43% ) and papilloma (n=131, 23% ) were the most common neoplasms. Premalignant lesions (n=10, 1.7% )- were dominated by primary acquired melanosis (PAM) with atypia and epithelial dysplasia. Malignant lesions constituted a total of 14 neoplasms (2.4% ), with basal cell carcinoma (n= 4, 0.7% ) and lymphoma (n=4, 0.7% ) being the most frequent. The preoperative clinical diagnosis was correct in 286 (50% )- of cases. Conclusion: Caruncular lesions are predominately benign but the lesions are rare and diverse, making clinical diagnosis difficult. Referral of excised lesions for pathological examination is recommended.