绝经后妇女HPV的持续性感染

作     者：Smith E.M. Johnson S.R. Ritchie J.M. 成健 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第3期

页      面：57-57页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：持续性感染 HPV 宫颈癌发病率 人类乳头瘤病毒 宫颈脱落细胞 鳞状上皮内病变 癌前病变 生殖器恶性肿瘤 致瘤 斑点杂交 

摘      要：Objective: Persistence of human papillomavirus (HPV) is associated with an increased risk of developing cervical SIL and cancer in young women. Because this association in older, postmenopausal age women has received little attention, we evaluated persistence of HPV among women in this age ***: Women (n=105) ages 45- 64 were examined annually for 7 years to evaluate HPV in cervical cytologic specimens. PCR, dot blot hybridization and DNA sequencing were used to detect HPV ***: The cumulative prevalence of HPV was 34% , and 24% had HPV high risk oncogenic types which are associated with genital cancers. The most common oncogenic types were HPV- 16 (72% ) and HPV- 31 (16% ). The persistence rate of HPV infection was 16% . No specific risk factors were associated with repeat viral ***: Postmenopausal women are infected with persistent oncogenic HPV at a substantial rate, supporting the need for continued screening in postmenopausal women to detect preneoplastic genital lesions.