Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4^(+) T cells
作者机构：Department of General SurgeryGuangzhou Digestive Disease CenterGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510180China Chronic Disease LaboratoryInstitutes for Life Sciences and School of MedicineSouth China University of TechnologyGuangzhou 510006China Institute of Immunology and School of Life SciencesUniversity of Science and Technology of ChinaHefeiAnhui 230027China Center for Reproductive MedicineAnhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhuiChina Department of Gastroenterology and HepatologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Division of RheumatologyAllergy and Clinical ImmunologyUniversity of California at Davis School of MedicineDavisCAUSA Division of ImmunologyAllergy and RheumatologyUniversity of CincinnatiCincinnatiOH 45267USA
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2020年第17卷第2期
页 面：178-189页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100102[医学-免疫学] 10[医学]
基 金：This study was supported by the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S054) the National Natural Science Foundation of China(81601416,81430034,91542123) the National Key R&D Program of China(2017YFA0205600) a National Institutes of Health grant(DK090019)
主 题：Liver-resident NK Cholangitis CD4^(+)T cell Suppression
摘 要：Liver-resident NK cells are distinct from conventional NK cells and play an important role in the maintenance of liver *** liver-resident NK cells participate in autoimmune cholangitis remains ***,we extensively investigated the impact of NK cells in the pathogenesis of autoimmune cholangitis utilizing the well-established dnTGFβRII cholangitis model,NK cell-deficient(Nfil3−/−)mice,adoptive transfer and in vivo antibody-mediated NK cell *** data demonstrated that disease progression was associated with a significantly reduced frequency of hepatic NK *** of NK cells resulted in exacerbated autoimmune cholangitis in dnTGFβRII *** further confirmed that the DX5−CD11c^(hi) liver-resident NK cell subset colocalized with CD4^(+) T cells and inhibited CD4^(+) T cell *** expression microarray analysis demonstrated that liver-resident NK cells had a distinct gene expression pattern consisting of the increased expression of genes involved in negative regulatory functions in the context of the inflammatory microenvironment.
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