育龄妇女垂体促性腺激素腺瘤的诊断
Diagnosis of pituitary gonadotroph adenomas in reproductive-aged women作者机构:Dr. LAC+USC Medical Center Department of Obstetrics and Gynecology 1240 N. Mission Road Los Angeles CA 90033 United States
出 版 物:《世界核心医学期刊文摘(妇产科学分册)》 (Core Journal in Obstetrics/Gynecology)
年 卷 期:2006年第2卷第2期
页 面:23-24页
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:垂体瘤 实性占位 颗粒细胞瘤 育龄女性 阴道囊肿 组织学检查 原发不孕 双侧附件 绝经前女性 切除术
摘 要:Objective: To describe the clinical symptoms associated with the diagnosis of pituitary gonadotroph adenoma in premenopausal women. Design: Report of three separate cases. Setting: University medical center. Patient(s): Three patients: a 31-year-old woman with primary infertility, recurrent adnexal masses, and highly elevated estradiol level; a 30-year-old woman with recurrent multicystic ovaries following multiple cystectomies and transvaginal cyst aspirations, and elevated estradiol level; a 43-year-old woman with bilateral complex cystic adnexal masses and an elevated estradiol level, who under-went a total abdominal hysterectomy and bilateral salpingo-oophorectomy for a suspected granulosa cell tumor. Intervention(s): Transsphenoidal resection of a pituitary mass. Main Outcome Measure(s): Serum estradiol, FSH, and LH levels; transvaginal ultrasonography of the ovaries; histologic examination of pituitary tumors. Result(s): Transsphenoidal resection of pituitary adenomas resulted in normalization of serum estradiol and FSH levels and resolution of adnexal masses in two of the women. Conclusion(s): Pituitary gonadotroph adenoma must be considered in the differential diagnosis in reproductive-aged women presenting with the clinical symptom triad of new onset oligomenorrhea, bilateral cystic adnexal masses, and elevated estradiol and FSH levels with suppressed levels of LH; timely diagnosis may prevent unnecessary and potentially damaging surgical procedures.