Role of gap junctions between keratinocyte and melanocyte in melanogenesis
Role of gap junctions between keratinocyte and melanocyte in melanogenesis作者机构：Division of Biotechnology School of Life Sciences Manipal University Manipal-576104 India Department of Anatomy Kasturba Medical College Manipal University Manipal-5 76104 India
出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)
年 卷 期：2015年第10卷第6期
页 面：495-502页
核心收录：
学科分类：0710[理学-生物学] 081702[工学-化学工艺] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：Kasturba Medical College Department of Biotechnology, Ministry of Science and Technology, India, DBT Manipal University
主 题：melanocyte keratinocyte melanogenesis gap junctions cell communication
摘 要：The process ofmelanogenesis in melanocytes and the transport of melanin in the form ofmelanosomes to the neighboring keratinocytes are the key steps in human skin pigmentation. Keratinocytes and melanocytes interact in intricate manner to maintain the homeostasis. The present study was designed to understand the role of cell-cell interaction through the gap junctions between melanocytes and keratinocytes on melanogenesis. We show that, inhibition of the gap junctional activity between human keratinocytes and melanocytes in a coculture system using gap junction blocker lowers the expression of key regulatory genes of melanogenesis such as tyrosinase and microphthalmia- associated transcription factor （MITF）. This was followed by concurrent decrease in tyrosinase protein levels and activity. Our results show the preliminary evidence for the regulation of melanogenesis in melanocytes through direct gap junctional communication by keratinocytes. Deciphering the mechanism and factors involved in the process would uncover the significance of gap junctions in melanogenesis.
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