Exogenous neural stem cell transplantation for cerebral ischemia

作     者：Ling-Yi Liao Benson Wui-Man Lau Dalinda Isabel Sánchez-Vidana Qiang Gao 

作者机构：Department of Rehabilitation MedicineWest China HospitalSichuan University Department of Rehabilitation SciencesThe Hong Kong Polytechnic University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第7期

页      面：1129-1137页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.0040205401797(to QG) the General Research Fund of China,No.15164216(to BWML) 

主　　题：nerve regeneration stem cell therapy neural stem cells cell transplantation ischemic stroke cerebral ischemia neuroplasticity functional recovery neural regeneration 

摘      要：Cerebral ischemic injury is the main manifestation of stroke,and its incidence in stroke patients is 70–80%.Although ischemic stroke can be treated with tissue-type plasminogen activator,its time window of effectiveness is narrow.Therefore,the incidence of paralysis,hypoesthesia,aphasia,dysphagia,and cognitive impairment caused by cerebral ischemia is high.Nerve tissue regeneration can promote the recovery of the aforementioned dysfunction.Neural stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain tissue.Neural stem cell transplantation for ischemic stroke has been a hot topic for more than 10 years.This review discusses the treatment of ischemic stroke with neural stem cells,as well as the mechanisms of their involvement in stroke treatment.