Effect of ciliary neurotrophic factor on the reactive astro-gliosis of cultured astrocytes from newborn rat brain

作     者：XIAN Haiqing FAN Ming YU Shun LIU Shuhong DING Aishi Ml Ruifa QIU Zongyin 

作者机构：Chongqing Medical UniversityChongqing 400046China Institute of Basic Medical SciencesAcademy of Military Medical ScienceBeijing 100850China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2001年第46卷第2期

页      面：129-133页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：ciliary neurotrophic factor astrogliosis mechanical scratch model. 

摘      要：The effect of ciliary neurotrophic factor (CNTF) on reactive astrogliosis was studied on a mechanical scratch model of the confluent astrocytic cultures from newborn rat brain. Following injury, the astrocytes at the edge of the injured area displayed a typical process of the reactive astrogliosis. This process included apparently hyperplastic change and significantly increased GFAP expression of the flat astrocytes, and migration to the injured area of the O-2A progenitor cells and their differentiation into process-bearing astrocytes. Exogenous CNTF applied to the cell cultures significantly promoted the hyperplasia and GFAP expression of the flat astrocytes. The results suggest that CNTF can enhance the reactive astrogliosis in the injured area.