Reverse Genetics for Peste des Petits Ruminants Virus: Current Status and Lessons to Learn from Other Non-segmented Negative-Sense RNA Viruses

作     者：Alfred Niyokwishimira Yongxi Dou Bang Qian Prajapati Meera Zhidong Zhang 

作者机构：State Key Laboratory of Veterinary Etiological BiologyLanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences CAAS-ILRI Joint Laboratory for Ruminant Disease ControlLanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2018年第33卷第6期

页      面：472-483页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 090601[农学-基础兽医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 

基　　金：supported by the National Key Research and Development Program of China (2016YFD0500108 and 2016YFE0204100) the International Cooperation Project of CAAS Innovation Program (CAAS-GJHZ201700X) 

主　　题：Peste des petits ruminants(PPR) PPRV Reverse genetics Non-segmented negative-sense RNA virus 

摘      要：Peste des petits ruminants(PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus(PPRV)pathobiology and molecular biology is critical for effective control and eradication of the disease. To achieve these goals,establishment of stable reverse genetics systems for PPRV would play a key role. Unfortunately, this powerful technology remains less accessible and poorly documented for PPRV. In this review, we discussed the current status of PPRV reverse genetics as well as the recent innovations and advances in the reverse genetics of other non-segmented negative-sense RNA viruses that could be applicable to PPRV. These strategies may contribute to the improvement of existing techniques and/or the development of new reverse genetics systems for PPRV.