Synthesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives

作     者：Xing ZHENG Jian Guo CAO Duan Fang LIAO Bing Yang ZHU Hui Ting LIU 

作者机构：Institute of Pharmacy ＆ Pharmacology Nanhua University Hengyang 421001 Cancer Research Institute Nanhua University Hengyang 421001 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第11期

页      面：1439-1442页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：湖南省教育厅科研项目(04C555) 

主　　题：Anticancer activity gem-difluoromethylenated chrysin. 

摘      要：Ten gem-difluoromethylenated chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of gem-difluoromethylenated chrysin derivatives had higher anticancer activity than chrysin.