Blockade of CD154-CD40 pathway induces interleukin-10 dependent T regulatory type 1 like cells

作     者：CAI Yong YANG Yi-rong XIA Peng ZHENG Shao-ling 

作者机构：Department or Transplantation First Affiliated Hospital ofWenzhou Medical College Wenzhou 325000 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2006年第119卷第6期

页      面：518-522页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

主　　题：CD154-CD40 T regulatory type 1 cells interleukin-10 rapamycin 

摘      要：Several subsets of T-regulatory （Tr） cells with distinct phenotypes and distinct mechanisms of action have been identified. These include Tr type 1 （Trl） cells; Th3 cells, which primarily secrete transforming growth factor （TGF）-β; and CD4^＋CD25^＋ T cells, which inhibit immune responses through cell to cell contact.1 It has been shown that CD4^＋CD25^＋ immunoregulatory T cells induced by the blockade of CD154-CD40 pathway are tolerant to alloantigen, resulting in secondary mixed lymphocyte reaction （MLR） hyporesponsiveness in vitro and tolerance to alloantigen in vivo. Previous studies mainly paid attention to CD4^＋CD25^＋ immunoregulatory T cells induced by CD154-CD40 blockade, but it was unclear whether CD154-CD40 blockade might induce Trl or Tr1-like cells.