Clinical Observation on Side Effects of Various Tripterygium Wilfordii Preparations

作     者：周嘉陵 朱琦 杨晓凌 张芳 

作者机构：Guanghua Hospital of Integrated Traditional Chinese and Western Medicine 200052 Shanghai 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：1999年第5卷第3期

页      面：171-175页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Tripterygium wilfordii preparation rheumatoid arthritis side effect 

摘      要：Objective: To observe the side effects of various Tripterygium wilfordii (TW) preparations in treating rheumatoid arthritis (RA). Methods: The total of 271 patients with RA were treated with various TW preparations to observe the occurrence of side effects. Results: The influence on reproductive system with TW preparations extracted from the TW leaves (Leino ester tablet, LE) was milder than that extracted from the roots (TW tablets and TW polyglycoside tablets, TWP). In the TWP group, the rate of side effect of 60 mg daily was higher than that of 30 mg daily, P 0.01. The main effects on digestive system and irregular menstruation occurred before 50 years in age, while it was kidney impairment after the age of 50. Those side effects occurred within the first ten years in long term application. The side effects of TWP produced in the Damp Heat Stagnation type of RA was much lower than Liver and Kidney Yin Deficiency type of RA, P 0.05. Conclusion: TW Leino ester tablet is indicated for young woman, and small dosage of TWP tablet is indicated for maintenance therapy, particularly to the Damp Heat type of RA.