Soothing Efficacy and Tolerability of a Skin Care Product Containing Live Lactobacillus rhamnosus Bacteria and Berry Seed Oils on Atopic Dermatitis Lesions

作     者：Beata Imko-Walczuk Aleksandra Taraszkiewicz Annika Mayra 

作者机构：Dermscan PolandGdanskPoland Gutguide Ltd.HelsinkiFinland 

出 版 物：《Journal of Cosmetics, Dermatological Sciences and Applications》 (化妆品、皮肤病及应用期刊（英文）)

年 卷 期：2019年第9卷第2期

页      面：83-93页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Atopic Dermatitis Lactobacillus rhamnosus Probiotic Berry Seed Oils Pruritus 

摘      要：Background: Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease characterized by a reduced microbiome diversity which favours the skin colonization with pathogenic bacteria, mainly with Staphylococcus aureus. A novel approach to the management of several skin diseases, including AD, involves the use of specific beneficial probiotic bacteria aimed at restoring the skin microbiome balance and decreasing the skin colonization with pathogens. Objective: This study assessed the soothing efficacy and tolerability of a new probiotic-based skin care product combining two live Lactobacillus rhamnosus strains and berry seed oils on eczematous lesions in subjects with atopic skin. Patients and Methods: Twenty-five adults with atopic skin and presenting at least one inflammatory lesion applied the product on the defined lesion for 28 days, once to twice daily. Severity of eczema signs (EASI score) and intensity of pruritus (VAS) were assessed, and digital images were captured following treatment. Cutaneous tolerability and subject satisfaction were also investigated. Results: A statistically significant decrease in mean EASI score was observed after 28 days (-27%, p = 0.011). A visible improvement in skin aspect was observed in 67% of the subjects on week 4. On average, the intensity of pruritus decreased by 57% as compared to baseline (p = 0.011). This effect was observed in 86% of the subjects. No relevant adverse reactions were observed following treatment with the skin care product and the majority of the subjects appreciated the product for its general characteristics, properties, and efficacy. Conclusion: The results suggest that this skin care product containing two live Lactobacillus rhamnosus strains and berry seed oils could be used for the treatment of eczematous lesions in subjects with atopic skin.