Copper-Catalyzed Carbotrifluoromethylation of Unactivated Alkenes Driven by Trifluoromethylation of Alkyl Radicals
作者机构：Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China School of Materials and Chemical Engineering Ningbo University of Technology No. 201 Fenghua Rood Ningbo Zhejiang 315211 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2019年第37卷第5期
页 面：452-456页
核心收录：
基 金：the National Basic Research Program of China(973 Program)(Grant 2015CB931900) the National Natural Science Foundation of China(Grants 21421002,21472220,2153200&21602239 and 21871285) the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant XDB20020000) the Shanghai Scientific and Technological Innovation Project(18JC1410600)
摘 要：Summary of main observation and conclusion We report herein an unprecedented protocol for radical carbotrifluoromethylation of unactivated alkenes. With Cu(OTf)2 as the catalyst, the reaction of unactivated alkenes, TMSCF3 and activated alkyl chlorides at room temperature provides the corresponding carbotrifluoromethylation products in satisfactory yields. Directed by trifluoromethylation of alkyl radicals, the method exhibits an excellent regioselectivity that is opposite to those driven by CF3 radical addition.
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