Assessing progression of keratoconus: novel tomographic determinants

作     者：Joshua K.Duncan Michael W.Belin Mark Borgstrom 

作者机构：Department of Ophthalmology&Vision ScienceUniversity of ArizonaTucsonAZUSA University of ArizonaUniversity Information Technology ServicesTucsonAZUSA 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2016年第3卷第1期

页      面：49-57页

核心收录：

学科分类：1204[管理学-公共管理] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Keratoconus Tomography Ectatic disease Progression Amsler-Krumeich Scheimpflug Collagen cross-linking 

摘      要：Several methods have been described in the literature to both evaluate and document progression in keratoconus,but there is no consistent or clear definition of ectasia *** authors describe how modern corneal tomography,including both anterior and posterior elevation and pachymetric data can be used to screen for ectatic progression,and how software programs such as the Enhanced Reference Surface and the Belin-Ambrosio Enhanced Ectasia Display(BAD)can be employed to detect earlier ***,in order to describe specific quantitative values that can be used as progression determinants,the normal noise measurement of the three parameters(corneal thickness at the thinnest point,anterior and posterior radius of curvature(ARC,PRC)taken from the 3.0 mm optical zone centered on the thinnest point),was *** values were obtained by imaging five normal patients using three different technicians on three separate *** 95%and 80%one-sided confidence intervals for all three parameters were surprisingly small(7.88/4.03μm for corneal thickness,0.024/0.012 mm for ARC,and 0.083/0.042 mm for PRC),suggesting that they may perform well as progression determinants.