The role of GSK3beta in the development of the central nervous system

作     者：Jia LUO 

作者机构：Department of Internal Medicine University of Kentucky College of Medicine Lexington KY 40536 USA 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2012年第7卷第3期

页      面：212-220页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 071006[理学-神经生物学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：National Institutes of Health  NIH  (AA015407  AA017226  AA019693) 

主　　题：development differentiation neurogenesis proliferation 

摘      要：Glycogen synthase kinase 3β（GSK3β） is a multifunctional serine/threonine kinase. It is particularly abundant in the developing central nervous system （CNS）. Since GSK3β has diverse substrates ranging from metabolic/ signaling proteins and structural proteins to transcription factors, it is involved in many developmental events in the immature brain, such as neurogenesis, neuronal migration, differentiation and survival. The activity of GSK3β is developmentally regulated and is affected by various environmental/cellular insults, such as deprivation of nutrients/ trophic factors, oxidative stress and endoplasmic reticulum stress. Abnormalities in GSK3β activity may disrupt CNS development. Therefore, GSK3β is a critical signaling protein that regulates brain development. It may also determine neuronal susceptibility to damages caused by various environmental insults.