Ischemic preconditioning partially suppresses and postpones integrin α_Vβ_3 mRNA expression following transient global cerebral ischemia in C57BL/6 mice

作     者：Mei Liu Xiaomeng Ma Xiaohong Chen Ying Jiang Aimin Wu Fuhua Peng Yingying Liu Rongbiao Pi 

作者机构：Department of Neurology the Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630 Guangdong Province China Department of Pharmacology and Toxicology School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510020 Guangdong Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第23期

页      面：1782-1786页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071007[理学-遗传学] 071003[理学-生理学] 

基　　金：the National Natural Science Foundation of China,No. 30870849,81071068 the Science and Technology Planning Project of Guangdong Province,No. 2009B030801101 

主　　题：integrin αvβ3 ischemic preconditioning ischemic tolerance global cerebral ischemia blood-brain barrier： mice 

摘      要：Previous studies of integrin αvβ3 have focused on ischemic brain damage, although the role of integrin αvβ3 in ischemic preconditioning （IP） has rarely been reported. The present study analyzed the effects of IP on integrin αvβ3 mRNA expression following cerebral ischemia through the use of hematoxylin-eosin staining and real-time quantitative polymerase chain reaction techniques. Integrin avid3 mRNA expression in the ischemia group peaked at 24 hours after ischemia-reperfusion. In the IP ＋ ischemia group, integrin αvβ3 mRNA expression increased after 24 hours, but remained significantly less than the ischemia group, and expression continued to increase until 7 days after ischemiaJreperfusion. These results demonstrate that IP effectively attenuated upregulation of integrin αvβ3 mRNA expression at 24 hours after ischemia.