Dental stem cell and dental tissue regeneration
作者机构：State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral DiseasesCenter for Tissue EngineeringFourth Military Medical UniversityXi’an 710032China Xi’an Institute of Tissue Engineering and Regenerative MedicineXi’an 710032China Department of Oral and Maxillofacial SurgeryGeneral Hospital of Shenyang Military Area CommandShenyang 110840China State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of StomatologyDepartment of Operative Dentistry and EndodonticsSchool of StomatologyFourth Military Medical UniversityXi’an 710032China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2019年第13卷第2期
页 面：152-159页
核心收录：
学科分类：10[医学]
基 金：the grants from the National Natural Science Foundation of China (Nos.31501121,31401255,81570976,and 31500786) Natural Science Foundation research project of Shaanxi Province (Nos.2016JQ8019 and 016KW-005)
主 题：stem cells pulp regeneration periodontal regeneration
摘 要：The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important function in mastication, articulation, and aesthetics. These characteristics, to a certain extent, greatly complicate the research in tooth regeneration. Recently, new ideas for tooth and tissue regeneration have begun to appear with rapid developments in the theories and technologies in tissue engineering. Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells (DPSCs), stem cells isolated from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs). All these cells can regenerate the tissue of tooth. This review outlines the cell types and strategies of stem cell therapy applied in tooth regeneration, in order to provide theoretical basis for clinical treatments.
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