免疫原性热休克蛋白-70在高度微卫星不稳定性结肠直肠癌中的过度表达

作     者：Banerjea A. Feakins R.M. Nickols C.D. 王晓君 

作者机构：Centre for Academic Surgery Alexandra Wing Royal London Hospital E1 1BB Whitechapel London United Kingdom Dr. 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2006年第2卷第5期

页      面：25-26页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：热休克蛋白-70 微卫星不稳定性 结肠直肠癌 肿瘤免疫原性 过度表达 Hsp-70 直肠癌患者 免疫组化法检测 抗肿瘤免疫反应 预后不良 

摘      要：PURPOSE: Colorectal cancers that display high-degree microsatellite instability are associated with an improved prognosis and evidence of an activated host immune response. Molecular analyses have suggested that heat shock proteins, a family of proteins that have key immunologic functions, are upregulated in these cancers. We aimed to explore the expression of heat shock proteins 70 and 110 and their relationship to microsatellite instability, survival, and other clinicopathologic parameters. METHODS: Twenty-six colorectal cancers that displayed microsatellite instability were matched by age, stage, and site in the colorectum to 26 microsatellite-stable cancers. Immunohistochemistry was used to detect expression of both markers. RESULTS: The microsatellite-unstable group showed significantly higher expression of heat shock protein 70 than the microsatellite-stable group (P = 0.006), and patients undergoing curative resections for unstable cancers had improved prognosis compared with their stable counterparts (P = 0.026). Significantly, in a multivariate survival analysis, low or absent heat shock protein 70 expression was independently associated with a poor outcome (P = 0.001). CONCLUSIONS:Heat shock protein 70 has known functions that promote antitumor immune responses. Its overexpression in colorectal cancers with microsatellite instability may be pivotal to explaining these tumors’ enhanced immunogenicity and improved prognosis.