Brevipedicelones D and E,Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity

作     者：Mirabel Akongwi Anastasie ETih Kennedy D.Nyongbela Moses Samje Raphael T.Ghogomu Bernard Bodo 

作者机构：Department of Organic ChemistryFaculty of ScienceUniversity of Yaounde 1P.O.Box 812YaoundeCameroon Pharmacochemistry Research LaboratoryDepartment of ChemistryFaculty of ScienceUniversity of BueaP.O.Box 63BueaSouth West RegionCameroon Faculty of ScienceANDI Centre of Excellence on Onchocerciasis ResearchUniversity of BueaP.O.Box 63BueaSouth West RegionCameroon Laboratoire de Chimie des Substances NaturellesMuse´um National d’Histoire Naturelle63 Rue Buffon75005 ParisFrance 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2019年第9卷第1期

页      面：61-68页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Mirabel Akongwi gratefully acknowledges sup-port by the ministry of higher education of Cameroon(MINESUP)for financial support 

主　　题：Garcinia brevipedicellata Brevipedicelone Anti-onchocercal activity 

摘      要：A novel isoflavone–chromone flavonoid C–O–C dimmer,brevipedicelone D(1),along with one new C–O–C biflavonoid derivative,brevipedicelone E(2),were isolated from the ethyl acetate extract of the leaves of Garcinia brevipedicellata,a medicinal plant used in folk medicine in parts of *** structures were elucidated by extensive spectroscopic techniques,including 1D-and 2D-NMR,MS experiments,as well as comparing their spectral data with those of known ***-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60%at the highest concentration(20 μg/mL)and inhibited motility of both the juvenile worms of *** and Loa loa by 90%at this same concentration.