A New Gastroprotective Effect of Limonoid Compounds Xyloccensins X and Y from Xylocarpus Molluccensis in Rats
作者机构：Division of Medicinal and Process ChemistryCentral Drug Research InstituteLucknow 226001UPIndia Department of BiochemistryKing George Medical UniversityLucknow 226003India Division of PharmacologyCentral Drug Research InstituteLucknow 226001UPIndia
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2014年第4卷第5期
页 面：277-283页
学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学] 10[医学]
基 金：Ministry of Earth Sciences Council of Scientific and Industrial Research, India, CSIR Ministry of Earth Sciences, एमओईएस
主 题：Gastric ulcer Xyloccensins X?Y Antiulcerogenic activity
摘 要：Gastric ulcer is a very common gastrointestinal disorder affecting a large number of people *** arises due to an imbalance between aggressive(acid,pepsin and Helicobacter pylori infection)and protective(mucin secretion,prostaglandin,epidermal growth factors and bicarbonate)factors in the *** this study,the gastroprotective activity has been investigated of the active constituents from Xylocarpus *** activity of xyloccensins X?Y was investigated and found to be active in various ulcer models in Sprague–Dawley(SD)*** understand the mechanism of action of active constituent of natural products,the effects of the compounds on antisecretory and cytoprotective activities were *** dried fruits were extracted with ethanol and fractionated into four *** X?Y were isolated from the active fraction and was tested against different ulcer *** X?Y were found to possess anti-ulcerogenic *** antiulcer activity might be due to its anti-secretory activity and subsequent strengthening of the defensive *** present study has helped us in identifying a new lead in the form of xyloccensins that could be exploited in the treatment of gastric ulcer disease.
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